This fast-paced underworld drama revolves around Bhai (Akkineni Nagarjuna), a fearless man, who is the most skilled and trusted enforcer, of a Hong Kong-based don named David (Ashish Vidyarthi). David is heavily dependent on Bhai for his day-to-day operations, and his sons James (Sonu Sood) and Tony (Ajay) resent Bhai's presence and power.
David sends Bhai to Hyderabad to finish off an undercover police officer who is disrupting the mafia operations in the city. In due course, Bhai bumps into Radhika (Richa Gangopadhyay), a horticulturist who falls in love with Bhai after a few incidents. However, Bhai never accepts her proposal. Bhai begins hunting down the undercover officer and uncovers his identity.
The police officer is none other than Arjun (Prasanna), and Bhai decides to finish him off. On the day of the trial, Bhai finds out that Arjun is his brother after seeing his father Raghava (Nagineedu) along with Arjun. He drops the plan and tries to walk out from the place, but the visuals of Bhai aiming at Arjun with a gun are recorded about which Bhai is not aware of.
However, Arjun is attacked by a few disguised armed men and all of them are killed by Arjun. Much to the shock of Bhai, one of the deceased is Tony, who sets out to India on the suggestion of James in order to kill Arjun and gain David's appreciation. David is taken aback after realizing the truth and is hell bent on killing Arjun.
Bhai's associate Munna (Adithya Menon) asks Bhai about his strange behavior at the murder spot. Then he narrates his past to Munna. Bhai aka Vijay is Raghava's son who resides in a village near Warangal. His father is a well-respected man in the village and Venkat Reddy (Jaya Prakash Reddy) is his opponent. Vijay used to spend his time with his siblings Arjun and Geetha.
The annual fest held at the temple becomes the bone of contention between Raghava and Venkat Reddy, as Raghava is hosting the function and Venkat Reddy does not want the fest to take place at all. Venkat Reddy sends his son to set things on fire at the fest. He is found setting fire by Raghava, who locks him in a room. The kid dies due to an unexpected injury caused by Raghava unintentionally which he was not aware of.
Vijay takes the blame and is arrested to save his father's goodwill. After he returns from the jail, Vijay ends up bashing Venkat Reddy's men. Raghava is infuriated due to this and he expels Vijay from his house. Vijay reaches Hyderabad and subsequently joins David and the mafia. Can Bhai get back at David and his other enemies, while reconciling and bonding with his family and friends?